The fresh endpoints Operating system, AFS, and you can independence out-of amputation was in fact analysed having fun with multivariable time-established Cox regression designs for the the full design (all customers) in accordance with sex-telecommunications terms and conditions per exposure factor. This new designs to own freedom off amputation considered death since a competing exposure in contrast to the latest AFS activities, including https://kissbrides.com/sv/heta-vietnamesiska-kvinnor/ demise throughout the endpoint. For this specific purpose, we used Good and you may Gray’s method of imagine sub-distributional threat rates (HRs) on the AFS design.

The models included risk profiles of patients at baseline and additionally time-dependent occurrence of comorbidities or procedures in the follow-up period. Thus, we evaluated the interaction of sex with all variables in the Cox regression models. Two-sided P-values for the test of interaction of the two models were jointly adjusted using the Benjamini–Hochberg procedure 34 to control the false discovery rate (FDR) with respect to the multiple testing problem. (suite…)